Alaska reported the largest increase in overdose deaths of any state by a significant margin. Alaska experienced a 74% jump in overdose deaths from 2020 to 2021. And, we are on track this year to be just as deadly. Last year, six out of 10 overdose/poisoning deaths in Alaska were linked to Fentanyl. (AK DHSS ) In addition, Alaska Natives have experienced more overdoses than other ethnic groups.